Gout is caused by a defect in metabolism that results in an overproduction of uric acid, or a reduced ability of the kidneys to eliminate uric acid. The exact cause of the metabolic defect is unknown. The disorder may also develop in people with diabetes mellitus, obesity, sickle cell anemia and kidney disease, may also occur after therapy with drugs that interfere with the excretion of uric acid.
Gout has four phases: asymptomatic (without symptoms), acute, intercritical and chronic. In acute gouty arthritis, symptoms develop suddenly and usually involve only one or a few joints. The pain frequently starts during the night and is usually described comolatejante, devastating and overwhelming. The link appears infected with signs of warmth, redness and sensitivity. The attacks of painful joints may subside within a few days, but may recur at irregular intervals. Subsequent attacks tend to last longer. In some people, can progress to chronic gouty arthritis, while in others there are no further attacks.